Transcription Factor 7-Like-2 (TCF7L2) rs7903146 (C/T) Polymorphism in Patients with Type 2 Diabetes Mellitus

Abstract Background Type 2 diabetes mellitus (T2DM) is a heterogeneous group of metabolic disorders characterized by the incapability pancreatic beta cells to increase insulin secretion compensate for resistance in peripheral tissues. T2DM multi-factorial disease including several environmental factors with presence genetic predisposition. The transcription factor 7-like-2 gene (TCF7L2) rs7903146 (C/T) polymorphism one most susceptible genes discovered date, contribution through Wnt/β –catenin signaling pathway affecting islet development, expression involved granules exocytosis and incretin glucagon-like peptide 1 (GLP-1) gene. Aim Work In this study we aimed investigate potential association patients type mellitus. Patients Methods was case- control conducted on 70 recruited from endocrinology clinic at Ain Shams University Hospitals, 30 non diabetic healthy controls matched age sex. All subjects underwent full history taking, thorough clinical examination, routine laboratory investigations haemoglobin A1c (HbA1c), lipid profile; total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C) low (LDL-C) determination TCF7L2 real-time quantitative polymerase chain reaction (RT-PCR). Results minor T allele rs7903146(C/T) SNP associated risk development an OR 1.35 (95% CI: 0.68-2.6), heterozygous genotype (CT) 1.16 0.49-2.7) homozygous mutant (TT) 3.16 0.15-6.31), however, they were statistically insignificant (p-value >0.05). Conclusion Our did not confirm significant between T2DM, it pointed possibility TT genotype. Further studies higher sample size are needed clarify association.